The goal here is for Spider-Byte to be a free play out of your hand. At the time of this review, there are 5 Tech cards in Protection and 2 in Basic (one of which is limited to Guardian identities). Many of the Protection Tech cards fill similar roles and you probably don't want to over-stuff your deck with all of them.
Clearly the best place for Margo is in the deck of a with lots of Tech cards in its hero kit, especially if the deck rewards you for playing those tech cards in other ways. I added her to my SP//dr deck and never looked back (web-warrior shenanigans being an extra bonus), but she could easily be slotted into an Iron Man, Black Widow, Rocket, War Machine, or Nick Fury Deck.
Assuming you can get her on the table for free, 4 thwart over 2 turns is nothing to sneeze at, especially in Protection, an aspect that often has trouble dealing with threat and that doesn't really need another chump blocker. Still worth it for 1 resource, maybe for 2, but if you are paying full price, you probably could have put those resources to better use.