Always Winterize Your Pipes

Somewhat of a modified pre-constructed deck but focusing on burst damage from Take That! after a few basic attacks from Iceman or allies once you're built. Cryokinetic Perception and Utopia can be used to help ready Iceman to allow more Frostbites and further damage.

X-Gene can be substituted for Deft Focus as well as using Moira MacTaggert for card draw and Player Side Schemes to help build setup. Ideally, with more damage you can try to defeat the villain before there is even enough time to let the main scheme or side schemes get out of control with the hopes that Frostbite will keep the scheme down as well as a well timed Chill Out! or Professor X. Flipping to Alter-Ego only to heal if needed or replace ice cards like Chill Out. If you have built enough Frostbite around the villain and minions the scheme for that turn should be manageable.

Defending on suspected big hits or using allies to block will help with health or putting Ice Wall out there to last a few more turns, while getting ready to finish.

If you have the turns to set up Boot Camp and Tac Team then it just makes placing damage that much easier, otherwise they will be used as resources for ice cards or allies. War Room is easy to set up and most likely will keep some threat down.

Now I am fairly new to the game, only play true solo and standard, don't have every hero pack/expansion (yet lol), and still testing this deck through different villains and scenarios, but I think it's a reasonable start.