Nothing goes over my head

I've seen some decks where Drax doesn't take damage after his initial three for vengeance, but Armored Vest and Electrostatic Armor hurt his nipples. There are also a lot of defensive events that ready your hero or stun the enemy if you take no damage, which are great but not very thematic. Two basic elements of Drax are that his cards are based on his vengeance staying at 3 (not flipping), Mantis healing him, and getting DWI Theet Mastery out as fast as possible for card draw.

Strategy: Mulligan for DWI Theet Mastery and Drax's Knife to work toward a ATK 5 stat for Limitless Stamina, and keep Mantis for healing. Limitless Stamina normally isn't very efficient but is once you have 3 vengeance on Drax.

Keep #Mantis on deck with Med Teams. She won't be enough for Drax to take hits to the face, so use Shake it Off and What Doesn't Kill Me when you can. Groot can take multiple minion hits and recover if they're under 3 damage. That is an amazing ability, so keep him on deck. The rest of the Guardians are more for theme but good in their own ways and blocking. Use C.I.T.T on yourself to ready, to use a 5 ATK, then to Theet draw a card.

Get Behind Me! is just a great card to avoid treacheries, especially to help out the team. I couldn't Drax Genius. Just. No.

Pretty simple but thematic and fun.