Waspzilla

So I've had a go at deck-building where you try a few things that might come off here and there.

Not this time; let's keep it simple.

Get Wasp in Giant form and keep her there.

Buffing up her DEF with Armored Vest and Soaring Acrobatics gets you to a 4 DEF as standard.

Plenty of readying in the form of Desperate Defense (giving you 6 DEF and unlikely to take damage), Earth's Mightiest Heroes, What Doesn't Kill Me and Indomitable should mean you have plenty of options for keeping a lid on threat, especially with Hard to Ignore to chip away at it too.

As her attacks are pretty strong and with this amount of readying, you should be able to stomp the villain into the ground.

Throw in some healing from Pym Particles, What Doesn't Kill Me, The Night Nurse and Med Team and all being well, you shouldn't need to drop down too often.

Resource generation / cost reduction comes from Quincarrier and Helicarrier with Avengers Tower to reduce the pricey Allies and all being well, your wings will be flapping more than me after a hot curry.